Samantha Who? (television) Half-hour ABC television series debuting on October 15, 2007, and ended on July 23, 2009. Following a hit-and-run accident that leaves her with amnesia, Sam Newly learns that she wasn’t a particularly honest, good-hearted, or loving person in the past. She thus has a rare opportunity to start anew and rediscover who she really is. Stars Christina Applegate (Sam Newly), Jennifer Esposito (Andrea), Jean Smart (Regina).